Senior Director, Clinical Programs

May 27, 2026

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The Senior Director of Clinical Programs will lead high-impact programs that advance GeneDx’s mission in rare disease diagnostics and precision medicine. This includes direct program ownership as well as managing a team of clinical program managers. This role is responsible for driving strategic initiatives within the Clinical Development team, including clinical research programs, medical input on product development, and regulatory support. The position requires strong leadership, deep expertise in clinical molecular genetics, and the ability to collaborate across internal teams and external stakeholders, including clinicians, academic collaborators, key opinion leaders (KOLs), and biopharma partners. Job Responsibilities <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="1" data-aria-level="1">Evidence Generation Strategy: Support the design and execution of evidence generation strategies for established clinical programs that cover clinical settings and diseases/disorders of interest (e.g., neurodevelopmental disorders, inpatient rapid genomic testing, genomic newborn screening, and other clinical indications) in collaboration with R&D, Commercial, Regulatory, Market Access, and Operations teams. Spearhead strategic initiatives within Medical Affairs to support GeneDx’s growth and innovation goals. </li> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="2" data-aria-level="1">Design and Execution of Internal Clinical & Translational Research: Lead and oversee clinical research projects that utilize internal GeneDx data and align with established clinical programs. This includes the direct development and execution of projects within assigned clinical programs as well as oversight of a team of clinical program managers. Collaborate with internal partners, including clinical data scientists, health economics and outcomes researchers (HEOR), and Product, to design and execute projects. Project oversight includes ensuring strategic alignment of internal research projects with the broader evidence generation strategy, prioritization, resource allocation, and regular reporting to Medical Affairs/Clinical Development leadership as well as leading applicable study meetings. </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="3" data-aria-level="1">Collaborations and Partnerships: Partner with internal and external stakeholders on prospective clinical and translational research efforts aligned with established clinical programs to deliver on project and program objectives. Identify and establish strategic collaborations with academic institutions, research organizations, and key opinion leaders (KOLs). Manage relationships with external partners to drive collaborative research projects, including clinicians, KOLs, and other strategic partners. Collaborate with internal partners, including Clinical Research Operations and Legal, to support contracting and project execution. Direct cross functional research project teams with internal and/or external interest holders, providing expert guidance and fostering a collaborative environment. </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="4" data-aria-level="1">Publication Management: Oversee the development, review, and submission of scientific manuscripts, abstracts, posters, and other publications aligned with established clinical programs. Collaborate with internal and external authors to produce high-quality scientific content. </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="5" data-aria-level="1">Scientific and Clinical Leadership: Acts as a subject matter expert for rare diseases and genomic diagnostics (including inpatient and outpatient testing, screening indications, and other clinical settings or indications of interest) for both internal teams and external stakeholders. Represent GeneDx at scientific conferences, clinical meetings, and other industry events. Deliver high quality presentations on GeneDx research and quality standards. Provide medical support internally for medical, product, and commercial strategy as well as scientific messaging. Provide medical support as needed for FDA and other regulatory submissions. Solve complex problems and lead innovative solutions that drive organizational success. </li> </ul> People Manager <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="6" data-aria-level="1">Yes </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="7" data-aria-level="1">Lead Team of Clinical Program Managers: Lead and mentor clinical program managers, including resource allocation, coaching and performance feedback, career development support. Foster a collaborative, high-performing team culture. </li> </ul> Education, Experience, and Skills <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="1" data-aria-level="1">PhD, MD (or equivalent) with board certification by the American Board of Medical Genetics and Genomics (or equivalent) required </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="2" data-aria-level="1">10+ years of experience in a clinical laboratory or industry role as a board certified ABMGG fellow required </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="3" data-aria-level="1">5+ years of experience in a medical affairs or clinical development role required </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="4" data-aria-level="1">5+ years of experience leading research efforts related to molecular diagnostics in rare disease required </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="5" data-aria-level="1">Strong level of clinical genetics knowledge in rare disease </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="6" data-aria-level="1">Strong publication record </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="7" data-aria-level="1">Ability to work cross-functionally with other teams and external collaborators to drive strategic initiatives forward </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="8" data-aria-level="1">Experience working with rare disease biopharma preferred </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="9" data-aria-level="1">Experienced in solving complex problems and negotiating business deals. </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="10" data-aria-level="1">Excellent written and verbal communication skills </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="11" data-aria-level="1">Exceptional presentation and public speaking skills </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="12" data-aria-level="1">Ability to work independently and manage time effectively </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="13" data-aria-level="1">Detail-oriented with strong organizational skills </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="14" data-aria-level="1">Proven experience leading teams and managing cross-functional collaborators to deliver on goals of projects and programs </li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{" 335552541":1,"335559685":1800,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="15" data-aria-level="1">Proficient in working with databases and Microsoft Office Suite. </li> </ul> Certificates, Licenses, Registrations <ul> <li data-leveltext="" data-font="Symbol" data-listid="7" data-list-defn-props="{" 335552541":1,"335559685":1080,"335559991":360,"469769226":"symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridmultilevel"}"="" data-aria-posinset="1" data-aria-level="1">Certification by the American Board of Medical Genetics and Genomics (ABMGG) or equivalent in clinical molecular genetics or laboratory genetics and genomics (LGG) </li> </ul> #LI-REMOTE<div class="content-pay-transparency"><div class="pay-input"><div class="title">Pay Transparency, Budgeted Range</div><div class="pay-range">$267,772—$305,413 USD</div></div></div><div class="content-conclusion">~ Science - Minded, Patient - Focused. At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care. Experts in what matters most. With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry’s genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust. SEQUENCING HAS THE POWER TO SOLVE DIAGNOSTIC CHALLENGES. From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way: TECHNICAL EXPERTISE <ul> <li style="text-align: left;">High-quality testing: Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.</li> <li style="text-align: left;">Advanced detection: By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.</li> </ul> CLINICAL EXPERTISE <ul> <li style="text-align: left;">Thorough analysis: We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.</li> <li style="text-align: left;">Customized care: Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.</li> <li style="text-align: left;">Impactful discovery: Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.</li> </ul> Learn more About Us <a href="https://www.genedx.com/about-us" target="_blank">here</a>. <div class="column _8-col center-element _12-col-tab"> <div class="margin-bottom margin-24"> <h3 class="heading-l">A culture that plays to win, because patients are counting on us</h3> </div> </div> <div class="column _8-col _12-col-tab"> At GeneDx, we're driven by urgency and purpose: helping patients get diagnosed earlier. Our mission, to empower everyone to live their healthiest life through genomics, drives our team to make a tangible impact each day – and shapes our culture where high standards, strong teamwork, and meaningful ownership are the norm. We act with intention, support one another, and deliver work we're proud to put our names on. Here’s what you can expect day to day: 1. Play like a champion (step up, redefine what’s possible, own it) We bring energy, focus, and a bias for action. We step up, take initiative, and deliver on our commitments – with quality, speed, and care. <div class="card-number">2. Think bigger (stretch beyond, courage not consensus)</div> We push past the obvious. We challenge assumptions, raise the bar, and make thoughtful, decisive calls — choosing progress over perfection. <div class="card-number">3. Grow fast (be curious, speak up, be agile)</div> We stay curious, ask questions, and share direct feedback with respect. We adapt quickly and keep learning through collaboration and continuous improvement. If you’re motivated by meaningful work, a fast-moving environment, and teammates who care deeply about outcomes, you’ll thrive at GeneDx. </div> Benefits include: <ul style="text-align: left;"> <li>Paid Time Off (PTO)</li> <li>Health, Dental, Vision and Life insurance</li> <li>401k Retirement Savings Plan</li> <li>Employee Stock Purchase Plan</li> <li>Employee Discounts</li> <li>Voluntary benefits</li> <li>Programs for parents and parents-to-be <ul style="text-align: left;"> <li>We provide expert support for family planning, pregnancy, and postpartum care, including up to 22 weeks of fully paid parental leave (U.S.) and up to $25K annually for fertility, adoption, or surrogacy.</li> </ul> </li> </ul> GeneDx is an Equal Opportunity Employer. All privacy policy information can be found <a href="https://www.genedx.com/privacy" target="_blank">here</a>.</div>

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